All About AMPK Activators
To ensure that the body is functioning properly, AMPK is crucial as it is regulating the maintenance of cellular energy homeostasis. In mammals, AMPK regulates the energy balance both on whole body level via response to the hormones and the brain and on cellular levels by way of sensing ATP/AMP and ATP/ADP ratio levels.
In the body, the most important energy molecule that is present is ATP. To make it simpler, this is the point where cellular function starts. Because energy is being used by cells, ATP is breaking down into ADP which has less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
There are different mechanisms in which AMPK acts on. This totally makes sense because it’s the master regulator of the functioning of cells. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – AMPK activation is gradually declining as we are aging. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. This promotes cellular renewal and at the same time, production of new mitochondria.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:
Number 1. AICAR – in AMP, AICAR is considered as its analog that is necessary for cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.